Liverpool suffered their first Champions League defeat of the season on 4 November, losing 3-2 to Fenerbahce in Istanbul after twice holding the lead, with manager Andoni Iraola pointing to poor defending as the cause.

According to The Straits Times, which carried an AFP report, the result handed a memorable win to Fenerbahce's interim coach Dirk Kuyt, who played six years at Anfield. Kuyt was only in his second match in charge following the departure of Ismail Kartal last week.

Iraola's side had won all three of their earlier European fixtures, which allowed him to rest Alexander Isak and Florian Wirtz as part of five changes from the 1-0 loss to Arsenal on 1 November.

Trey Nyoni, who kept his place, opened the scoring with his first goal for Liverpool, striking from the edge of the area after the hosts failed to deal with a Dominik Szoboszlai cross. Fenerbahce responded four minutes later when a deflected Mason Greenwood free kick wrong-footed Alisson Becker.

Iraola introduced Isak, Wirtz and Cody Gakpo shortly after the hour, and the move paid off almost straight away as Isak was left unmarked to head home a Gakpo delivery. The advantage did not last. A cross struck Gakpo and ran past Alisson, leaving Archie Brown with a simple finish at the far post. Vedat Muriqi then won the contest, holding off Jeremy Jacquet to direct a header into the bottom corner.

That was the 10th goal Liverpool have conceded across four Champions League matches. Iraola acknowledged his side had controlled spells and found the net, but said that when they conceded, "we should definitely defend better".

Isak played down concerns, saying Liverpool's earlier results meant one defeat was no crisis and that a win in their next game would restore a strong position.

The loss denied Liverpool the chance to draw level with Paris Saint-Germain at the top of the standings. The report noted Liverpool were also beaten twice away at Galatasaray last season.

Fenerbahce, who had collected only two points from their first three games, climb to 19th in the 36-team table. The top eight advance directly to the last 16, while sides from ninth to 24th enter a two-legged play-off.